Figure S10 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8+ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Key Points

• IGM-7354 significantly boosts NK and CD8+ T cell proliferation against PD-L1-positive tumor cells.
• The immune response mechanism involves heightened cytotoxicity mediated by IGM-7354.
• Effective interaction between immunocytokine IGM-7354 and immune cells was observed in mouse models.
• Findings suggest IGM-7354's role in enhancing cancer immunotherapy approaches targeting PD-L1.

Abstract