Supplementary Figure S2 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Key Points

• Multi-selective inhibition of RAS(ON) significantly lowers pERK expression in PDAC tumors.
• The findings highlight the role of T-cell activity in tumor regression and responses observed.
• The research utilizes preclinical models to explore the effects of targeted inhibition on pancreatic tumors.
• This work advances understanding of treatment strategies for pancreatic ductal adenocarcinoma, emphasizing immune system involvement.

Abstract