Supplementary Figure 17 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• SPP1+ tumor-associated macrophages are linked to CD8 T-cell dysfunction, driving resistance to immunotherapy.
• Analysis reveals a correlation between SPP1+ infiltrating macrophages and BAP1 mutations in clear-cell renal cell carcinoma.
• Observational analysis highlights crucial mechanisms of immunotherapy resistance in ccRCC, influenced by tumor microenvironment.
• Understanding these interactions may enable novel strategies to improve patient outcomes in ccRCC treatment.

Abstract