Supplementary Figure 6 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• SPP1+ TAMs negatively impact progression-free survival after immunotherapy in clear-cell renal cell carcinoma.
• The study demonstrates a significant association between TAM infiltration and CD8 T-cell dysfunction.
• Clear-cell renal cell carcinoma patients with high TAM presence may experience worse immunotherapy outcomes.
• Understanding TAMs role could lead to new strategies in managing immunotherapy resistance in ccRCC.

Abstract