An Immune Cell Activation Signature for Non - Small Cell Lung Cancer Revealed Tumor Microenvironment Heterogeneity and the Role of RORA in Regulating ZNF490/NDUFA12 Axis

Key Points

• Effective model captures the heterogeneity of non-small cell lung cancer (NSCLC) tumors, showing varied immune responses.
• RORA promotes ZNF490 expression, which in turn inhibits nuclear dehydrogenases and lowers oxidative phosphorylation processes.
• Understanding the RORA-ZNF490/NDUFA12 axis could lead to new therapeutic approaches in NSCLC management.
• Highlights the necessity to explore tumor microenvironment's role in shaping immune cell activity and cancer progression.

Abstract