Gastroprotective effect of Kahweol against ethanol-induced gastric ulcer by employing in silico, in vitro and in vivo approaches

Key Points

• Kahweol significantly reduced the size of ethanol-induced gastric ulcers, demonstrating notable gastroprotective effects.
• Treatment with 50 mg/kg Kahweol resulted in a 60% reduction in ulcer area compared to control.
• Assessment using in silico, in vitro, and in vivo approaches provided insight into the mechanisms behind Kahweol’s effects.
• Findings support the potential of Kahweol as a dietary supplement for ulcer prevention, but further clinical research is needed.