March 3, 2026Open Access

Evaluating metagenomic sequencing as a stool-based diagnostic in children with presumptive TB in Uganda

Key Points

Metagenomic sequencing did not enhance sensitivity for TB detection.
Novel diagnostic targets were identified for potential molecular testing improvements.
Stool DNA analysis presents a non-invasive option for TB assessment in children.
Enhancing TB diagnostics can lead to better health outcomes in resource-limited settings.

Abstract

Metagenomic sequencing of stool DNA did not increase sensitivity of TB detection, but identified novel targets for molecular testing that may support development of more sensitive tests.

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Authors

Carolina Agudelo

University of California, Berkeley

Moses Nsereko

Mulago Hospital

Deus Atwiine

Mulago Hospital

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Institutions

University of California, Berkeley

University of California, San Francisco

University of California System

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Evaluating metagenomic sequencing as a stool-based diagnostic in children with presumptive TB in Uganda

Key Points

Abstract

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Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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