Unimolecular GLP ‐1/Apelin Hybrid Peptides Cause Prominent Appetite Suppression, as Well as Enhancing Insulin Secretion, Beta‐Cell Survival and Glycaemic Regulation
Key Points
To explore the therapeutic potential of GLP-1/apelin hybrid molecules for obesity and T2DM management.
Designed and synthesized GLP-1/apelin hybrid peptides
Evaluated the effects on appetite and insulin secretion
Assessed beta-cell survival and glycaemic regulation
Improved beta-cell survival and glycaemic regulation noted
Abstract
These studies highlight the clear therapeutic applicability of rationally designed GLP-1/apelin hybrid molecules for the treatment of obesity and T2DM.
الببتيدات الهجينة أحادية الجزيء GLP-1 / Apelin تسبب قمعًا بارزًا للشهية، بالإضافة إلى تعزيز إفراز الأنسولين، وبقاء خلايا بيتا، وتنظيم سكر الدم | Synapse