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The genetic alterations identified in melanomas at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.
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John A. Curtin
Jane Fridlyand
Toshiro Kageshita
New England Journal of Medicine
University of California, San Francisco
Memorial Sloan Kettering Cancer Center
Seoul National University
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Curtin et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d6bfdbfca0359822aa8325 — DOI: https://doi.org/10.1056/nejmoa050092
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