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Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection. (Funded by the Medical Research Council and others.).
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Gerlinger et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d72b8a3f906f6a06bef907 — DOI: https://doi.org/10.1056/nejmoa1113205
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
Marco Gerlinger
Andrew J. Rowan
Stuart Horswell
New England Journal of Medicine
Harvard University
University College London
Technical University of Denmark
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