Cell Membrane Biomimetic Single-Atom Nanozymes for Combined Tumor Chemodynamic Therapy and Immunotherapy

In recent years, single atom nanozymes have attracted increasing attention in the antitumor field due to their excellent features such as efficient catalytic activity. However, chemotherapy alone is often insufficient to eradicate tumors and even less effective in inhibiting tumor recurrence and metastasis. Therefore, we developed a cell membrane biomimetic single-atom nanozyme (named MnGY@CCM) and used it for combined chemodynamic therapy-immunotherapy antitumor research. Manganese-doped graphyne (MnGY), a single atom nanozyme, catalyzes excessive hydrogen peroxide in the tumor microenvironment (TME) to generate reactive oxygen species (ROS), inducing immunogenic cell death of tumor cells. Cancer cell membrane (CCM) can both promote dendritic cell maturation and inhibit distant tumor growth in combination with an immune checkpoint blockade. In addition, we found that CCM not only did not affect but also enhanced the catalytic activity of MnGY. Therefore, the nanoplatform composed of MnGY and CCM exerted the advantages of chemodynamic therapy and immunotherapy and produced synergistic therapeutic results.