The Progression of Vaginal Intraepithelial Neoplasia to Cancer: A Systematic Review and Meta-Analysis

Key Points

• This review aims to assess the risk of high-grade vaginal intraepithelial neoplasia progressing to vaginal cancer.
• Conducted a systematic review and meta-analysis of existing studies
• Focused on high-grade vaginal intraepithelial neoplasia
• Evaluated treatment status of subjects (treated vs. untreated)
• Higher progression risk of high-grade VaIN to vaginal cancer than previously reported
• Untreated women face a more significant risk of progression
• Findings suggest the need for careful monitoring and potential intervention