What question did this study set out to answer?

This research aims to explore how accelerated epigenetic aging impacts cognitive decline associated with homocysteine levels.

April 10, 2026Open Access

Accelerated epigenetic aging as a modifier of homocysteine‐associated cognitive decline: Findings from NHANES

Key Points

This research aims to explore how accelerated epigenetic aging impacts cognitive decline associated with homocysteine levels.
Analyzed data from NHANES
Assessed the relationship between homocysteine and cognitive function
Investigated the role of epigenetic aging and neuroinflammation
Higher homocysteine levels are linked to increased cognitive decline.
Epigenetic aging exacerbates the cognitive effects of hyperhomocysteinemia.
Folate shows protective effects by lowering homocysteine levels.

Abstract

Epigenetic aging-associated neuroinflammation serves as a key mechanistic link between hyperhomocysteinemia and cognitive decline. The neuroprotective effects of folate are mediated specifically through homocysteine reduction, providing novel mechanistic insights for precision prevention strategies in cognitive aging.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Haoxuan Li

Yuhan Chen

Zhe Wang

Journals

Alzheimer s & Dementia

Actions

Institutions

Ministry of Education of the People's Republic of China

Hebei Medical University

Hebei University of Chinese Medicine

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Accelerated epigenetic aging as a modifier of homocysteine‐associated cognitive decline: Findings from NHANES

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider