What question did this study set out to answer?

To investigate the presentation and implications of disseminated histoplasmosis in a diabetic patient.

April 10, 2026Open Access

A silent aggressor: disseminated histoplasmosis with laryngeal and adrenal involvement in a diabetic patient

Key Points

To investigate the presentation and implications of disseminated histoplasmosis in a diabetic patient.
Clinical assessment of symptoms like hoarseness and fever
Diagnostic histopathology using fungal stains such as PAS, GMS, and LPCB
Evaluation of adrenal enlargement and function
Revealed presence of hoarseness, fever, and weight loss
Demonstrated adrenal enlargement without definitive insufficiency
Highlighted importance of clinical awareness in endemic regions and immunocompromised states

Abstract

Disseminated histoplasmosis can present with hoarseness, fever, weight loss and multi-organ involvement. Adrenal enlargement is common but may not always cause insufficiency. Histopathology and fungal stains (PAS, GMS, and LPCB) are diagnostic gold standards. High clinical suspicion is needed in endemic regions or immunocompromised hosts.

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Cite This Study

Singhal et al. (Wed,) studied this question.

synapsesocial.com/papers/69d8940c6c1944d70ce050a9 https://doi.org/https://doi.org/10.1530/edm-25-0137

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