What question did this study set out to answer?

The aim is to explore the effectiveness of quercetin-loaded lipid nanoparticles in targeting the hedgehog signaling pathway for myopia control in the retina.

April 10, 2026Open Access

Targeting the Hedgehog Signaling Pathway in the Retina Using Quercetin-Loaded Lipid Nanoparticles for Myopia Control

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Key Points

The aim is to explore the effectiveness of quercetin-loaded lipid nanoparticles in targeting the hedgehog signaling pathway for myopia control in the retina.
Utilized quercetin-loaded lipid nanoparticles (QLSs) for retinal application.
Evaluated aqueous solubility and bioavailability of QLSs.
Assessed dose-response efficacy for myopia control.
QLSs showed excellent aqueous solubility.
Significant efficacy observed with low-dose administration.
Promising implications for clinical applications in myopia treatment.

Abstract

QLSs exhibited excellent aqueous solubility and bioavailability, enabling low-dose administration with significant efficacy, thereby presenting great prospects for clinical application.

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Authors

Lianghui Zhao

Bin Guo

Xiaoyun Dong

Journals

Translational Vision Science & Technology

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Institutions

Shandong University of Traditional Chinese Medicine

Shandong Center for Disease Control and Prevention

Shandong Academy of Chinese Medicine

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Targeting the Hedgehog Signaling Pathway in the Retina Using Quercetin-Loaded Lipid Nanoparticles for Myopia Control

Key Points

Abstract

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Authors

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