Transcriptomic validation of a 7,12 Dimethylbenz(a)anthracene ( DMBA )‐induced leukemia rat model: Parallels with human leukemogenesis

Key Points

• The research aims to validate a leukemia rat model induced by DMBA and compare its transcriptomic profile with that of human leukemia.
• Utilized a DMBA-induced rat model to study leukemia.
• Conducted transcriptomic analysis to identify oncogenic features.
• Compared findings with human leukemia characteristics.
• The rat model displayed a transcriptomic profile similar to that found in human leukemia.
• Key oncogenic and prognostic features were identified in both the model and humans.
• The findings support the model's use for preclinical studies in leukemogenesis.

Abstract