What question did this study set out to answer?

The aim is to determine the prognostic role of soluble urokinase-type plasminogen activator receptor (suPAR) in predicting renal outcomes in glomerulonephritis patients.

April 10, 2026Open Access

Prognostic significance of soluble urokinase-type plasminogen activator receptor in patients with glomerulonephritis: association with renal outcomes

Key Points

The aim is to determine the prognostic role of soluble urokinase-type plasminogen activator receptor (suPAR) in predicting renal outcomes in glomerulonephritis patients.
Analyzed biopsy-proven primary glomerulonephritis cases.
Measured levels of soluble urokinase-type plasminogen activator receptor at biopsy.
Assessed the association between suPAR levels and renal function decline.
Higher suPAR levels at biopsy predicted a decline in estimated glomerular filtration rate (eGFR).
suPAR levels were not associated with changes in proteinuria over time.

Abstract

In patients with biopsy-proven primary GN, higher suPAR levels at biopsy independently predicted subsequent eGFR decline but not proteinuria change, supporting longitudinal suPAR assessment as a complementary tool for renal risk stratification.

Bookmark

View Full Paper

Cite This Study

Choi et al. (Wed,) studied this question.

synapsesocial.com/papers/69d895796c1944d70ce067a2 https://doi.org/https://doi.org/10.23876/j.krcp.25.294

Bookmark

View Full Paper