What question did this study set out to answer?

To evaluate the incidence of mold infections in lung transplant recipients on nebulized liposomal amphotericin B prophylaxis.

April 10, 2026

Breakthrough Mold Infections During Long-term Nebulized Liposomal Amphotericin B Prophylaxis in Lung Transplant Recipients: A Single-center Cohort (NEBULA Study)

Key Points

To evaluate the incidence of mold infections in lung transplant recipients on nebulized liposomal amphotericin B prophylaxis.
Conducted a single-center cohort study
Followed lung transplant recipients undergoing n-LAB prophylaxis
Monitored incidence of mold infections and tolerance over time
Low incidence of mold infections reported
Nonsusceptible molds did not increase mortality
Excellent tolerability of n-LAB prophylaxis maintained over prolonged follow-up

Abstract

Lifelong n-LAB prophylaxis was associated with a low incidence of mold infection during prolonged follow-up and maintained excellent tolerability. The emergence of amphotericin B-nonsusceptible molds was not associated with increased mortality.

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Discussion

Journals

Transplantation

Institutions

Universitat Autònoma de Barcelona

Instituto de Salud Carlos III

Vall d'Hebron Hospital Universitari

References and Citations

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