Semaglutide-Induced Symptomatic Remission in Ulcerative Colitis

Abstract Ulcerative colitis (UC) often requires immunosuppressive therapy for remission. Glucagon-like peptide-1 receptor agonists are used for diabetes and obesity, although their role in UC is unclear. We report a 42-year-old woman with left-sided UC and poorly controlled diabetes who achieved remission after initiating semaglutide. Despite persistent symptoms on maximal mesalamine, she declined immunosuppression. After semaglutide initiation, she achieved clinical remission by 8 weeks, with improved fecal calprotectin, metabolic parameters, and mucosal healing on follow-up colonoscopy. This case suggests a potential adjunctive role for glucagon-like peptide-1 receptor agonists in UC.