Subclinical and Borderline Rejection are Associated With Death‐Censored Graft Loss After Kidney Transplantation: A Systematic Review and Meta‐Analysis | Synapse
April 10, 2026Open Access
Subclinical and Borderline Rejection are Associated With Death‐Censored Graft Loss After Kidney Transplantation: A Systematic Review and Meta‐Analysis
Key Points
To evaluate the association between subclinical rejection (SCR) and borderline rejection (BLR) with long-term graft loss after kidney transplantation.
Conducted a systematic review and meta-analysis of relevant studies.
Included studies assessing SCR and BLR effects on graft outcomes.
Statistical analysis of graft loss rates associated with SCR and BLR.
SCR and BLR are linked to poorer long-term graft survival.
Both forms of rejection demonstrate a statistically significant association with graft loss.
Abstract
SCR and BLR are associated with inferior long-term graft outcomes. These findings underscore their prognostic significance and warrant prospective studies to determine optimal management strategies.