Synthesis of a New Nickel–Palladium Complex Catalyst and Its Application in Suzuki-Miyaura Reaction

A Ni-Pd complex catalyst with superior catalytic performance was successfully synthesized via coordination reactions between nickel and palladium salts and ethylene glycol dimethyl ether as the ligand. A series of 38 biaryl derivatives were efficiently synthesized through the Suzuki coupling reaction by using the new Ni–Pd complex catalyst. This synthetic protocol offers several advantages, including mild reaction condi­tions, low catalyst cost, and facile scalability, making it highly attractive for practical applications. Notably, under ambient temperature, liquid crystal monomer materials, 2-cyano-4′-methylbiphenyl and ethyl biphenyl­acetate, were efficiently synthesized with excellent yields exceeding 95%, and 2-(4-fluorophenyl)thiophene was synthesized in 83% yield. The catalyst cost for preparing the same amount of products using the new complex catalyst was only 8% of that required with the conventional Pd(PPh3)4 catalyst, highlighting the economic and synthetic advantages of the new system.