The novel ABC classification of intra-device thrombosis accurately predicted peri-device leak following left atrial appendage closure, with Type A indicating sealing and Type C indicating patency.
Observational
Blinded investigators for image analysis
No
Does a unifying ABC classification system reproducibly identify sealing and peri-device leak following left atrial appendage closure across different imaging modalities?
Patients following left atrial appendage closure
A unifying ABC classification system for assessing sealing and peri-device leak (PDL)
Association of classification types with sealing/PDL and reproducibility across imaging modalities and readerssurrogate
A new ABC classification system for assessing sealing after left atrial appendage closure is highly reproducible across imaging modalities and reader experience levels.
Type A was associated with sealing irrespective of imaging modality, while Type C was always an indicator of PDL. This unifying classification was highly reproducible across imaging modalities and among readers of differing levels of experience.
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Ali Hamadanchi
Victor Eskildsen
Jacob Johnsen
Clinical Research in Cardiology
Cornell University
Aarhus University Hospital
Weill Cornell Medicine
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Hamadanchi et al. (Mon,) conducted a observational in Non-valvular atrial fibrillation undergoing left atrial appendage closure (n=68). ABC classification of intra-device thrombosis (IDT) was evaluated on Peri-device leak (PDL) in Type A intra-device thrombosis at 90 days by CCT (95% CI 0.7%-14.5%, p=<0.001). The novel ABC classification of intra-device thrombosis accurately predicted peri-device leak following left atrial appendage closure, with Type A indicating sealing and Type C indicating patency.
www.synapsesocial.com/papers/69df2a99e4eeef8a2a6afa75 — DOI: https://doi.org/10.1007/s00392-026-02895-6