What does this research mean for the field?

High expression of PAPP-A predicts poor prognosis in estrogen receptor-positive (ER+) breast cancer and is correlated with the activation of the IGF-1/IGF-1R pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate the relationship between PAPP-A expression and prognosis in estrogen receptor-positive breast cancer.

April 15, 2026Open Access

High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients

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Key Points

This research aims to investigate the relationship between PAPP-A expression and prognosis in estrogen receptor-positive breast cancer.
Analyzed PAPP-A expression levels in breast cancer tissues
Correlated PAPP-A levels with clinical outcomes
Assessed activation of the IGF-1/IGF-1R pathway
Higher PAPP-A expression is linked to worse outcomes in ER-positive breast cancer
PAPP-A correlates with increased activation of the IGF-1/IGF-1R pathway

Abstract

High expression of PAPP-A is associated with poor prognosis in ER+ breast cancer and correlates with IGF-1/IGF-1R pathway activation.

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Discussion

Authors

Zeanap Mabruk

Esme Bullock

Xue Ming Xiao

Journals

Cancer Medicine

Actions

Institutions

Aarhus University

University of Electronic Science and Technology of China

Edinburgh Cancer Research

References and Citations

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Building similarity graph...

Analyzing shared references across papers

High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

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