large-animal model of ventricular desynchronization
Experimental dyssynchronous heart failure (DHF)
mitochondrial distribution and functions, regional workload and energy demandsurrogate
In a large-animal model of dyssynchronous heart failure, increased lateral wall workload leads to hypertrophy and metabolic homogenization, but ultimately results in energy starvation and systolic dysfunction.
Experimental DHF is characterised by non-fibrotic, dilated LV without signs of oxidative stress. Workload increase in the lateral wall leads to hypertrophy and EMID, homogenizing metabolic profiles between wall segments. However, the ventricle enters energy starvation and systolic dysfunction.
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Dietl et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69df2b2ce4eeef8a2a6b02af — DOI: https://doi.org/10.1093/ejhf/xuag112
Alexander Dietl
Sabine Iberl
Lisa Marie Kohler
European Journal of Heart Failure
KU Leuven
Medizinische Hochschule Hannover
University of Regensburg
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