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Research Paper | Synapse

April 15, 2026

Functional Endoscopic Sinus Surgery in Adults With CRSwNP Treated With Mepolizumab: Airway Physiology Outcomes From a Randomised Controlled Trial

Key Points

To evaluate the effects of mepolizumab on airway physiology outcomes following functional endoscopic sinus surgery in adults with CRSwNP.
Conducted a randomised controlled trial.
Administered mepolizumab to patients undergoing functional endoscopic sinus surgery.
Assessed airway hyperresponsiveness through bronchial challenges.
Airway hyperresponsiveness significantly improved after treatment with mepolizumab.
The improvement was particularly evident during indirect bronchial challenges.

Abstract

Summary Airway hyperresponsiveness improved after mepolizumab, particularly for indirect bronchial challenge. Analyses were exploratory and not pre‐specified in the randomised trial protocol.

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Authors

J

Jens Even Tidemandsen

University of Copenhagen

A

Anne Sophie Homøe

Copenhagen University Hospital

P

P. Gibson

John Hunter Hospital

Journals

Clinical & Experimental Allergy

Actions

Institutions

University of Copenhagen

University of Newcastle Australia

Copenhagen University Hospital

References and Citations

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Cite this study

Tidemandsen et al. (Mon,) studied this question.

synapsesocial.com/papers/69df2b65e4eeef8a2a6b0695 — DOI: https://doi.org/10.1111/cea.70304