Effects of locally applied water-filtered infrared a irradiation adjunctive to iloprost and carbon dioxide hand baths in patients with systemic sclerosis and severe Raynaud’s phenomenon – a randomized controlled trial | Synapse
April 15, 2026Open Access
Effects of locally applied water-filtered infrared a irradiation adjunctive to iloprost and carbon dioxide hand baths in patients with systemic sclerosis and severe Raynaud’s phenomenon – a randomized controlled trial
Key Points
The study investigates the impact of locally applied water-filtered infrared a during iloprost treatment in systemic sclerosis patients with severe Raynaud's phenomenon.
Randomized controlled trial design
Administration of water-filtered infrared a along with iloprost
Assessment of pain and Raynaud's phenomenon duration as outcomes
Short-term improvements in pain reported
Modest reductions in Raynaud's phenomenon duration observed
Safety of the adjunctive therapy was confirmed
Abstract
Adjunctive wIRA during iloprost therapy was safe and yielded modest, short-term improvements in pain and RP duration. These exploratory effects warrant confirmation in larger controlled trials.