Intramolecular difunctionalization of alkynes involving cascade radical 1,4-heteroaryl migrations and formal total synthesis of a β-imidazolyl-γ-lactam alkaloid: isoanantine

Key Points

• This research aims to develop a method for the intramolecular difunctionalization of alkynes, focusing on synthesizing β-heteroaryl-γ-lactams.
• Explored multiple versions of intramolecular difunctionalization of alkynes.
• Utilized various 1,4-heteroaryl migrations during the process.
• Investigated five nitrogen-containing heteroaromatics.
• Successfully produced a series of β-heteroaryl-γ-lactams.
• Demonstrated effective radical migrations.
• Provided a formal total synthesis pathway for isoanantine.