Supplementary Figure S8 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Key Points

• MAIN FINDING: Conventional dendritic cells play a key role in enhancing anti-tumor responses in pancreatic cancer models.
• KEY EVIDENCE: RAS(ON) multi-selective inhibition shows significant effects on tumor regression related to T-cell activity.
• APPROACH: The study utilized preclinical models to assess the impacts of RAS(ON) inhibition on tumor dynamics.
• SIGNIFICANCE: These findings could lead to improved treatment strategies for pancreatic ductal adenocarcinoma using T-cell activation.

Abstract