Supplementary Figure 7 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• SPP1+ TAM infiltration significantly correlates with reduced overall survival in ccRCC patients.
• Univariate Cox analysis indicates a relationship between SPP1+ TAMs and progression-free survival rates.
• The findings highlight the critical link between macrophage infiltration and T-cell dysfunction in immunotherapy outcomes.
• The results underscore the potential need for targeting TAMs to enhance immunotherapy responses.

Abstract