Supplementary Figure 16 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• SPP1+ TAMs are linked to CD8 T-cell dysfunction in clear-cell renal cell carcinoma, impacting treatment outcomes.
• The analysis demonstrates a significant correlation between SPP1+ TAMs infiltration and immune cell dynamics.
• The assessment of immune cell infiltration focuses on how these interactions may contribute to immunotherapy resistance.
• Understanding this relationship may provide insights for improved therapeutic strategies in renal cell carcinoma.

Abstract