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The purpose of this study is to evaluate hyaluronic acid (HA), sometimes referred to as hyaluronan or hyaluronate, as well as its derivatives and how they are used in cosmetic formulations. N-acetylglucosamine and D-glucuronic acid are the two disaccharides that make up HA, a glycosa-minoglycan that was first isolated from the vitreous humor of the eye and then found in other tissues and fluids, including the synovial fluid and articular cartilage. It is found in all vertebrates, including humans, and has a variety of roles in biological processes, such as wound healing, inflammation, cell differentiation, and embryological development. With its moisturizing and anti-aging properties, HA offers numerous advantages over other chemicals used in skin regeneration. The biological activity and skin penetration of HA are influenced by its molecular weight. The current study outlines the key elements of hyaluronic acid's usage in cosmetology, given its broad range of uses and applications in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, cancer, nutrition, and cos-metics. There is a discussion of the biological impact of HA at the skin's level as well as any possible negative consequences. From the brand portfolios of the most well-known manufacturers, a few read-ily available cosmetic items containing HA have been discovered, and their composition has been assessed.
Datta et al. (Mon,) studied this question.