February 24, 2024Open Access

Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15

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Abstract

Fusobacterium nucleatum (F. nucleatum) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. nucleatum-dependent carcinogenesis. Here, we identify that F. nucleatum is enriched preferentially in KRAS p.G12D mutant CRC tumor tissues and contributes to colorectal tumorigenesis in Villin-Cre/Kras

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Zhu et al. (Sat,) studied this question.

www.synapsesocial.com/papers/68e77b3bb6db6435876efd92 — DOI: https://doi.org/10.1038/s41467-024-45572-w

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Authors

Huiyuan Zhu

Man Li

Dexi Bi

Journals

Nature Communications

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Institutions

Tongji University

Yangzhou University

Fudan University Shanghai Cancer Center

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Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15

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Abstract

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Cite this study

Also consider

Authors

Journals

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