Synthesis and evaluation of 14β-acyl substituted 17cyclopropylmethyl-7,8-dihydromorphinone derivatives: mixed partial agonists at mu opioid and nociception/orphanin FQ peptide receptors
Key Points
This research aims to synthesize and evaluate new compounds that can manage severe pain with fewer side effects than traditional opioids.
Evaluate their activity as mixed partial agonists at mu opioid and nociception receptors.
Analyze their potential as analgesics in comparison to standard opioids.
Identified new derivatives with partial agonist properties at mu opioid receptors.
Showed reduced adverse effects compared to traditional opioids.
Suggested potential as effective treatments for chronic pain management.
Abstract
Opioids remain the standard of care for management of severe pain, but adverse effects limit their use, particularly for the treatment of chronic pain. Compounds that have dual partial agonist...
Synthesis and evaluation of 14β-acyl substituted 17cyclopropylmethyl-7,8-dihydromorphinone derivatives: mixed partial agonists at mu opioid and nociception/orphanin FQ peptide receptors | Synapse