Dose-dependent effects of atorvastatin on inflammatory response in endothelial cells: MMP/TIMP balance and in vitro wound closure assay

Key Points

• The aim is to explore how atorvastatin influences inflammatory responses and healing in endothelial cells based on dosage.
• Investigated effects of atorvastatin on endothelial cells under inflammatory conditions.
• Analyzed MMP (matrix metalloproteinases) and TIMP (tissue inhibitors of metalloproteinases) balance.
• Performed in vitro wound closure assays to assess healing.
• Evaluated different dosages of atorvastatin for their impact on recovery mechanisms.
• Atorvastatin demonstrated dose-dependent modulation of inflammatory responses in endothelial cells.
• Alterations in MMP/TIMP balance were observed with varying dosages.
• Enhanced wound closure was noted, indicating improved endothelial recovery with proper dosages.

Abstract