MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway

Key Points

• This research aims to explore the protective effects of MOTS-c against liver injury induced by acetaminophen (APAP) and the underlying mechanisms involved.
• Administered MOTS-c to mice exposed to acetaminophen
• Evaluated liver injury markers such as oxidative stress and inflammation
• Analyzed the MAPK signaling pathway components including ERK, JNK, and p38
• MOTS-c administration significantly reduced liver injury in mice
• The study found lower levels of oxidative stress and inflammation in treated mice
• MAPK signaling pathway suppression was confirmed, correlating with reduced cell death