Casein- and Soy-Based High-Protein Diets Differentially Affect Insulin Resistance and Adipose Tissue Advanced Glycation End Product Accumulation in Obese Diabetic Mice

Key Points

• Insulin resistance increased with casein-based high-protein diets but not with soy-based diets, highlighting food source variability.
• Glycer-AGE accumulation was greater in visceral adipose tissue among mice on casein-based diets, emphasizing its metabolic impact.
• The analysis involved obese diabetic mice to assess how dietary protein affects metabolic health outcomes.
• These findings imply that protein source choice may influence dietary strategies for managing insulin resistance.