Regulatory dynamics of IFI44L in systemic lupus erythematosus: the interplay of type I interferon and c-Jun | Synapse
March 3, 2026Open Access
Regulatory dynamics of IFI44L in systemic lupus erythematosus: the interplay of type I interferon and c-Jun
Key Points
Enhanced expression of IFI44L indicates its critical role in systemic lupus erythematosus.
Type I interferon was shown to increase IFI44L expression by engaging c-Jun, affecting disease dynamics.
Assessment suggests modulation of IFI44L expression could be a target for therapeutic intervention in autoimmune conditions.
The findings highlight the importance of regulatory mechanisms involving IFN-α and c-Jun in the pathogenesis of SLE.
Abstract
Our research indicates that IFN-α enhances IFI44L expression via c-Jun, underscoring its critical role in the pathogenesis of SLE and suggesting potential pathways for therapeutic intervention.