Immune checkpoint inhibitor rechallenge in advanced NSCLC: prognostic value of the neutrophil-to-lymphocyte ratio

Key Points

• NLR at ICI rechallenge emerged as a key prognostic factor for both progression-free survival and overall survival in advanced NSCLC.
• The study highlights the importance of validating prespecified cut-offs for NLR in prospective multicenter evaluations
• Assessment within composite inflammation and nutrition scores could enhance understanding of NLR’s prognostic capacity.
• Modest efficacy of immune checkpoint inhibitor rechallenge suggests further exploration is needed in varied treatment contexts.