Clinical evidence supports the feasibility, safety, and efficiency of CLE in neurosurgery, offering rapid intraoperative histology without tissue removal. Current studies remain observational with varying study design and outcome definition, limiting assessment of the effectiveness and impact. Well-designed interventional trials are needed to determine CLE's definitive role as an intraoperative optical biopsy tool guiding tumor resection and patient outcomes.
Xu et al. (Wed,) studied this question.