Endocrine regimen and early subclinical atherosclerosis in premenopausal HR+/HER2− breast cancer: real-world evidence and regimen-dependent effects of Sanhuang Decoction

Key Points

Early atherosclerosis is linked to a poor lipid profile in patients undergoing hormonal therapy.
Patients receiving aromatase inhibitors and ovarian function suppression show increased carotid plaque formation compared to those on Tamoxifen.
Assessment of regimen-dependent effects reveals significant differences in lipid levels influenced by Sanhuang Decoction use.
Careful cardiovascular monitoring is indicated for personalized treatment in this premenopausal population.

Abstract

In premenopausal women with HR+/HER2- breast cancer, AI+OFS was associated with an adverse lipid profile and a possible increase in carotid plaque compared with TAM-based regimens. Regimen-dependent associations between SHD and lipid profiles support individualized cardiovascular monitoring and cautious use of adjunctive SHD in this population.

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Endocrine regimen and early subclinical atherosclerosis in premenopausal HR+/HER2− breast cancer: real-world evidence and regimen-dependent effects of Sanhuang Decoction

Key Points

Abstract

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