Time to adopt a new standard method for assessing cardiac function in chemotherapy-induced cardiotoxicity in breast cancer? A systematic review and meta-analysis

Key Points

Global longitudinal strain outperforms left ventricular ejection fraction for detecting cardiotoxicity.
Analysis indicated that GLS is the recommended screening method based on comparative data from multiple studies.

Structured PICO

Does Global Longitudinal Strain (GLS) improve screening for chemotherapy-induced cardiotoxicity in breast cancer compared to isolated Left Ventricular Ejection Fraction (LVEF) assessment?

Population

Breast cancer patients at risk for chemotherapy-induced cardiotoxicity

Intervention

Global Longitudinal Strain (GLS) assessment

Comparator

Isolated assessment by Left Ventricular Ejection Fraction (LVEF)

Outcome

Screening/detection of cardiotoxicitysurrogate

Global Longitudinal Strain (GLS) is recommended as the preferred imaging modality over isolated LVEF for detecting chemotherapy-induced cardiotoxicity in breast cancer.

Abstract

Comparative analysis of data from our meta-analyses supports the recommendation of Global Longitudinal Strain (GLS) as the preferred method for screening for cardiotoxicity, over isolated assessment by Left Ventricular Ejection Fraction (LVEF).

Time to adopt a new standard method for assessing cardiac function in chemotherapy-induced cardiotoxicity in breast cancer? A systematic review and meta-analysis

Key Points

Structured PICO

Abstract

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