Fecal microbiota transplantation from gestational diabetes mellitus patients induces glucose intolerance and subclinical inflammation in mice

Key Points

• Glucose intolerance and subclinical inflammation occur after fecal microbiota transplantation.
• The GDM-FMT model reveals key metabolic dysregulations linked to gestational diabetes.
• Assessment using microbial dysbiosis indicates altered gut microbiota composition affects host metabolism.
• Findings highlight the need to explore therapeutic strategies targeting gut microbiota for managing gestational diabetes.

Abstract