March 3, 2026Open Access

Liver iron levels are associated with HFE-hemochromatosis genotype, diet, adiposity, and disease in the UK Biobank

Key Points

Undiagnosed C282Y+/+ individuals show excess liver iron compared to treated individuals, indicating treatment impact.
Genetic and environmental factors, such as diet and adiposity, play a significant role in liver iron levels.
The analysis suggests that addressing lifestyle factors could benefit those genetically predisposed to hemochromatosis.
Tailored advice may help reduce liver iron in at-risk individuals, enhancing their health outcomes.

Abstract

Undiagnosed C282Y+/+ individuals had excess liver iron versus diagnosed, likely due to treatment. Genetic and environmental factors influence liver iron beyond C282Y+/+. Tailored lifestyle advice could benefit those at risk of hemochromatosis.

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Discussion

Authors

Mitchell R. Lucas

Luke C. Pilling

João Delgado

Journals

Hepatology Communications

Actions

Institutions

University of Exeter

Royal Devon & Exeter NHS Foundation Trust

South Warwickshire NHS Foundation Trust

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Liver iron levels are associated with HFE-hemochromatosis genotype, diet, adiposity, and disease in the UK Biobank

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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