Development of zein-soy protein isolate-rutin supramolecular nanoparticles via pH-ultrasound-shifting method: Structural characterization, stability, and gastrointestinal bioaccessibility

Key Points

• Nanoparticles demonstrate significant stability and gastrointestinal bioaccessibility for rutin.
• The structural characterization indicates that the pH-ultrasound-shifting method yields effective supramolecular nanoparticles.
• Stable nanoparticles composed of zein and soy protein isolate enhance rutin's bioaccessibility significantly.
• Enhancing rutin delivery may aid in developing nutraceuticals for better health outcomes.