Alzheimer's disease as a systems-level timing disorder: Circadian disruption of glial immunometabolism, brain clearance, and therapeutic responsiveness | Synapse
March 3, 2026Open Access
Alzheimer's disease as a systems-level timing disorder: Circadian disruption of glial immunometabolism, brain clearance, and therapeutic responsiveness
Key Points
Therapeutic responsiveness is compromised due to circadian disruption in Alzheimer’s disease.
Key evidence shows that glial immunometabolism plays a crucial role in this disruption.
Analysis of circadian rhythms reveals significant impacts on brain clearance mechanisms in Alzheimer’s disease.
The findings suggest that understanding timing disorders may lead to improved therapies for Alzheimer’s patients.