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The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial | Synapse
March 3, 2026
The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial
HY
Hon Chi Yip
NU
Noriya Uedo
HI
Hiroyoshi Iwagami
Osaka International Cancer Institute
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Key Points
Diluted epinephrine significantly reduces bleeding during gastric endoscopic submucosal dissection procedures, indicating improved outcomes.
Bleeding incidents were lower in the group that received diluted epinephrine, with a notable decrease by 25% compared to controls.
Randomized controlled trial was conducted across multiple international centers over a period of six months, involving hundreds of patients.
Efficacy highlighted may suggest the need for broad implementation of diluted epinephrine in gastric procedures, enhancing recovery.
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Yip et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75dc3c6e9836116a27fee
https://doi.org/https://doi.org/10.1016/j.gie.2026.01.031