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Ex vivo transcriptional alterations in glutamatergic transmission in patients with multiple sclerosis | Synapse
March 3, 2026
Ex vivo transcriptional alterations in glutamatergic transmission in patients with multiple sclerosis
SA
Stella Angeloglou
ER
Elpida Repousi
MG
Melpomeni Galani
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Key Points
Transcriptional alterations were observed, impacting glutamatergic transmission in multiple sclerosis patients, indicating disease-related changes.
Key evidence shows significant changes in 5 transcriptional biomarkers linked to glutamatergic activity.
Analysis involved ex vivo assessments from patients diagnosed with multiple sclerosis, correlating with disease progression.
These findings highlight potential biomarkers that may improve understanding of multiple sclerosis' impact on neurotransmission.
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Angeloglou et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75e9ec6e9836116a29681
https://doi.org/https://doi.org/10.1016/j.jns.2025.123920