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Multistep receptor binding of the hepatitis B virus preS1 domain | Synapse
March 3, 2026
Open Access
Multistep receptor binding of the hepatitis B virus preS1 domain
CK
Chisa Kobayashi
Tokyo University of Science
TE
Toru Ekimoto
Yokohama City University Medical Center
KO
Koji Ooka
Tokyo University of the Arts
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Key Points
Receptor binding of the hepatitis B virus occurs in a multistep process, enhancing viral entry.
Key evidence shows that preS1 domain interactions are crucial for binding to host receptors.
Analysis of receptor binding specificity highlights distinct stages of the interaction process.
Findings indicate potential therapeutic targets, warranting further investigation into antiviral strategies.
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Kobayashi et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75ebec6e9836116a29a12
https://doi.org/https://doi.org/10.1038/s41467-025-68062-z