Evidence For a Fibrogenic Interaction Between the Aryl Hydrocarbon Receptor and the Wnt/β-Catenin Pathways in Human Keratinocytes and Fibroblasts | Synapse
March 3, 2026Open Access
Evidence For a Fibrogenic Interaction Between the Aryl Hydrocarbon Receptor and the Wnt/β-Catenin Pathways in Human Keratinocytes and Fibroblasts
Key Points
The study reveals a significant interaction between the aryl hydrocarbon receptor and the Wnt/beta-catenin pathway.
AHR plays a context-dependent role in skin fibrosis, impacting keratinocytes and fibroblasts.
The investigation highlights the involvement of transforming growth factor beta in these pathways.
These findings suggest potential targets for therapeutic intervention in skin fibrosis.
Abstract
The study demonstrates a context-dependent role of AHR in skin fibrosis and its interaction with TGFβ and Wnt/β-catenin signaling.