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Permissive Cardiotoxicity: Real World Outcomes of CAR-T Therapy in Patients with Heart Failure and Reduced Ejection Fraction | Synapse
March 3, 2026
Permissive Cardiotoxicity: Real World Outcomes of CAR-T Therapy in Patients with Heart Failure and Reduced Ejection Fraction
SL
Sree M Lanka
The Ohio State University
SC
Sayan Mullick Chowdhury
JS
Jeremy Sen
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
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Key Points
Cardiotoxicity rates increased, with significant implications for heart failure management and patient care,
The study reports a 40% incidence of cardiotoxicity related to CAR-T therapy in heart failure patients,
Observational analysis of real-world outcomes across multiple facilities highlights varied responses to treatment,
Findings may enable better monitoring strategies and tailored interventions for heart failure patients under CAR-T therapy.
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Cite This Study
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Lanka et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76028c6e9836116a2ca0e
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.242